Publications
- 2022
Gene Therapy in Orthopaedics: Progress and Challenges in Pre-Clinical Development and Translation.
Frontiers in bioengineering and biotechnology. 10. [DOI] 10.3389/fbioe.2022.901317. [PMID] 35837555.
2 citations | PubMed | Publisher's Site - 2021
Fast SARS-CoV-2 virus detection using disposable cartridge strips and a semiconductor-based biosensor platform.
Journal of vacuum science and technology. B, Nanotechnology & microelectronics : materials, processing, measurement, & phenomena : JVST B. 39(3). [DOI] 10.1116/6.0001060. [PMID] 34055475.
8 citations | PubMed | Publisher's Site - 2021
Orthopaedic Gene Therapy: Twenty-Five Years On.
JBJS reviews. 9(8). [DOI] 10.2106/JBJS.RVW.20.00220. [PMID] 34437305.
6 citations | PubMed | Publisher's Site - 2018
Arthritis Gene Therapy Approved in Korea.
The Journal of the American Academy of Orthopaedic Surgeons. 26(2):e36-e38. [DOI] 10.5435/JAAOS-D-17-00695. [PMID] 29303924.
11 citations | PubMed | Publisher's Site - 2018
Arthritis gene therapy is becoming a reality.
Nature reviews. Rheumatology. 14(7):381-382. [DOI] 10.1038/s41584-018-0009-5. [PMID] 29743627.
24 citations | PubMed | Publisher's Site - 2018
Gene Delivery to Joints by Intra-Articular Injection.
Human gene therapy. 29(1):2-14. [DOI] 10.1089/hum.2017.181. [PMID] 29160173.
66 citations | PubMed | Publisher's Site - 2018
Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.
Human gene therapy. Clinical development. 29(2):90-100. [DOI] 10.1089/humc.2017.142. [PMID] 29869540.
28 citations | PubMed | Publisher's Site - 2018
Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery.
Current gene therapy. 18(3):154-170. [DOI] 10.2174/1566523218666180410152842. [PMID] 29637858.
14 citations | PubMed | Publisher's Site - 2018
Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations.
European cells & materials. 36:156-170. [DOI] 10.22203/eCM.v036a12. [PMID] 30311630.
2 citations | PubMed | Publisher's Site - 2018
Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.
Human gene therapy. Clinical development. 29(2):101-112. [DOI] 10.1089/humc.2017.143. [PMID] 29869535.
19 citations | PubMed | Publisher's Site - 2016
Liquid-like Solids Support Cells in 3D.
ACS biomaterials science & engineering. 2(10):1787-1795. [DOI] 10.1021/acsbiomaterials.6b00218. [PMID] 33440476.
50 citations | PubMed | Publisher's Site - 2016
MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 57(5):502-14. [DOI] 10.1111/vru.12369. [PMID] 27198611.
11 citations | PubMed | Publisher's Site - 2014
Animal models in osteosarcoma.
Frontiers in oncology. 4. [DOI] 10.3389/fonc.2014.00189. [PMID] 25101245.
51 citations | PubMed | Publisher's Site - 2014
Magnetic Resonance Imaging Scoring of An Experimental Model of Osteoarthritis in the Equine Carpus
22(S). - 2013
Arthritis gene therapy and its tortuous path into the clinic.
Translational research : the journal of laboratory and clinical medicine. 161(4):205-16. [DOI] 10.1016/j.trsl.2013.01.002. [PMID] 23369825.
52 citations | PubMed | Publisher's Site - 2013
Directed Evolution of Aav Capsid for Targeted Cancer Therapy
Molecular Therapy. 21. - 2013
Scaav Provides Sustained Expression of a Homologous Therapeutic Transgene in Large Mammalian Joints, With Enhanced Expression in Osteoarthritis
Molecular Therapy. 21. - 2013
scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.
Gene therapy. 20(6):670-7. [DOI] 10.1038/gt.2012.81. [PMID] 23151520.
45 citations | PubMed | Publisher's Site - 2012
An acidic oligopeptide displayed on AAV2 improves axial muscle tropism after systemic delivery.
Genetic vaccines and therapy. 10(1). [DOI] 10.1186/1479-0556-10-3. [PMID] 22709483.
2 citations | PubMed | Publisher's Site - 2012
Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells.
Arthritis research & therapy. 14(4). [DOI] 10.1186/ar3921. [PMID] 22817660.
51 citations | PubMed | Publisher's Site - 2012
Orthopedic gene therapy--lost in translation?
Journal of cellular physiology. 227(2):416-20. [DOI] 10.1002/jcp.23031. [PMID] 21948071.
22 citations | PubMed | Publisher's Site - 2011
Evidence for the osteosarcoma stem cell.
Current orthopaedic practice. 22(4):322-326. [PMID] 21755019.
31 citations | PubMed - 2011
Getting arthritis gene therapy into the clinic.
Nature reviews. Rheumatology. 7(4):244-9. [DOI] 10.1038/nrrheum.2010.193. [PMID] 21135882.
45 citations | PubMed | Publisher's Site - 2010
Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo.
Laboratory investigation; a journal of technical methods and pathology. 90(11):1615-27. [DOI] 10.1038/labinvest.2010.145. [PMID] 20697373.
49 citations | PubMed | Publisher's Site - 2009
Chondrogenesis of Bovine Mscs Is Influenced By Adenoviral-Mediated Delivery of Bmp-4, Bmp-7, Indian Hedgehog, and Sox-9
Molecular Therapy. 17. - 2009
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.
Human gene therapy. 20(2):97-101. [DOI] 10.1089/hum.2008.075. [PMID] 18986219.
50 citations | PubMed | Publisher's Site - 2009
Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer.
Tissue engineering. Part A. 15(5):1127-39. [DOI] 10.1089/ten.tea.2007.0252. [PMID] 18826340.
81 citations | PubMed | Publisher's Site - 2009
Examining the Role of Elevated Blood Glucose in the Severity of Arthrofibrosis Using Intra-Articular Gene Delivery of Tgf-Beta 1
Molecular Therapy. 17. - 2009
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma.
Cancer research. 69(14):5648-55. [DOI] 10.1158/0008-5472.CAN-08-3580. [PMID] 19584295.
137 citations | PubMed | Publisher's Site - 2009
Gene therapy of the rheumatic diseases: 1998 to 2008.
Arthritis research & therapy. 11(1). [DOI] 10.1186/ar2563. [PMID] 19232068.
26 citations | PubMed | Publisher's Site - 2009
Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer.
Arthritis research & therapy. 11(5). [DOI] 10.1186/ar2822. [PMID] 19799789.
106 citations | PubMed | Publisher's Site - 2009
Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.
The journal of gene medicine. 11(7):605-14. [DOI] 10.1002/jgm.1334. [PMID] 19384892.
44 citations | PubMed | Publisher's Site - 2009
Orthopedic gene therapy in 2008.
Molecular therapy : the journal of the American Society of Gene Therapy. 17(2):231-44. [DOI] 10.1038/mt.2008.265. [PMID] 19066598.
52 citations | PubMed | Publisher's Site - 2009
Progress and Prospects: genetic treatments for disorders of bones and joints.
Gene therapy. 16(8):944-52. [DOI] 10.1038/gt.2009.73. [PMID] 19675584.
29 citations | PubMed | Publisher's Site - 2009
Transduction of Equine Joint Tissues With Self-Complementary Adeno-Associated Virus
Molecular Therapy. 17. - 2008
A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors.
Gene therapy. 15(5):357-63. [DOI] 10.1038/sj.gt.3303092. [PMID] 18283289.
13 citations | PubMed | Publisher's Site - 2008
Arthritis gene therapy's first death.
Arthritis research & therapy. 10(3). [DOI] 10.1186/ar2411. [PMID] 18510784.
60 citations | PubMed | Publisher's Site - 2008
Perspectives on the use of gene therapy for chronic joint diseases.
Current gene therapy. 8(4):273-86. [PMID] 18691023.
11 citations | PubMed - 2008
Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.
Journal of virology. 82(15):7467-74. [DOI] 10.1128/JVI.02720-07. [PMID] 18508896.
13 citations | PubMed | Publisher's Site - 2007
[Gene therapy for osteoarticular disorders].
Medecine sciences : M/S. 23(3):303-9. [PMID] 17349293.
1 citation | PubMed - 2007
Facilitated endogenous repair: making tissue engineering simple, practical, and economical.
Tissue engineering. 13(8):1987-93. [PMID] 17518747.
98 citations | PubMed - 2007
Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid.
Tissue engineering. 13(9):2227-37. [PMID] 17561802.
54 citations | PubMed - 2007
Major biological obstacles for persistent cell-based regeneration of articular cartilage.
Arthritis research & therapy. 9(3). [PMID] 17561986.
222 citations | PubMed - 2007
Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(6):1114-20. [PMID] 17440444.
40 citations | PubMed - 2006
Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta.
Arthritis research & therapy. 8(6). [PMID] 17109745.
51 citations | PubMed - 2006
Gene therapeutic approaches-transfer in vivo.
Advanced drug delivery reviews. 58(2):243-58. [PMID] 16563557.
40 citations | PubMed - 2006
Gene therapy for arthritis: what next?
Arthritis and rheumatism. 54(6):1714-29. [PMID] 16729280.
42 citations | PubMed - 2006
Will arthritis gene therapy become a clinical reality?
Nature clinical practice. Rheumatology. 2(7):344-5. [PMID] 16932715.
8 citations | PubMed - 2005
Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 23(1):118-26. [PMID] 15607883.
66 citations | PubMed - 2005
Gene therapy for the treatment of musculoskeletal diseases.
The Journal of the American Academy of Orthopaedic Surgeons. 13(4):230-42. [PMID] 16112980.
42 citations | PubMed - 2005
Gene transfer to human joints: progress toward a gene therapy of arthritis.
Proceedings of the National Academy of Sciences of the United States of America. 102(24):8698-703. [PMID] 15939878.
132 citations | PubMed - 2005
Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(2):219-28. [PMID] 16043093.
107 citations | PubMed - 2005
Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy.
Gene therapy. 12(2):177-86. [PMID] 15578043.
72 citations | PubMed - 2005
Stem-like cells in bone sarcomas: implications for tumorigenesis.
Neoplasia (New York, N.Y.). 7(11):967-76. [PMID] 16331882.
375 citations | PubMed - 2005
The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics.
Arthritis research & therapy. 7(6):273-8. [PMID] 16277703.
3 citations | PubMed - 2004
Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes.
Osteoarthritis and cartilage. 12(3):217-24. [PMID] 14972338.
25 citations | PubMed - 2004
Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 22(1):66-72. [PMID] 14656661.
71 citations | PubMed - 2004
Gene delivery to cartilage defects using coagulated bone marrow aspirate.
Gene therapy. 11(2):133-41. [PMID] 14712297.
77 citations | PubMed - 2004
Gene-based approaches for the repair of articular cartilage.
Gene therapy. 11(4):351-9. [PMID] 14724680.
90 citations | PubMed - 2004
In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.
Methods in molecular medicine. 100:147-64. [PMID] 15280594.
17 citations | PubMed - 2004
Osteoarthritis gene therapy.
Gene therapy. 11(4):379-89. [PMID] 14724685.
99 citations | PubMed - 2004
The 2003 Nicolas Andry Award. Orthopaedic gene therapy.
Clinical orthopaedics and related research. (429):316-29. [PMID] 15577504.
54 citations | PubMed - 2003
A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer.
Arthritis research & therapy. 5(5):R301-9. [PMID] 12932294.
32 citations | PubMed - 2003
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees.
Arthritis research & therapy. 5(3):R132-9. [PMID] 12723985.
76 citations | PubMed - 2003
Gene transfer to articular chondrocytes with recombinant adenovirus.
Methods in molecular biology (Clifton, N.J.). 215:235-46. [PMID] 12512303.
27 citations | PubMed - 2003
Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium.
Gene therapy. 10(12):1055-60. [PMID] 12776164.
51 citations | PubMed - 2003
Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy. 7(4):460-6. [PMID] 12727108.
64 citations | PubMed - 2002
Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices.
Human gene therapy. 13(7):791-802. [PMID] 11975846.
44 citations | PubMed - 2002
Development of gene-based therapies for cartilage repair.
Critical reviews in eukaryotic gene expression. 12(4):259-73. [PMID] 12641395.
17 citations | PubMed - 2002
Gene transfer approaches to the healing of bone and cartilage.
Molecular therapy : the journal of the American Society of Gene Therapy. 6(2):141-7. [PMID] 12161179.
82 citations | PubMed - 2002
Genetic approaches to the repair of connective tissues.
Annals of the New York Academy of Sciences. 961:65-7. [PMID] 12081867.
1 citation | PubMed - 2002
Genetic approaches to tissue engineering: breakout session summary.
Annals of the New York Academy of Sciences. 961:71-2. [PMID] 12081869.
1 citation | PubMed - 2002
In organello footprinting of mtDNA.
Methods in molecular biology (Clifton, N.J.). 197:363-75. [PMID] 12013810.
PubMed - 2002
In vivo gene delivery to synovium by lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy. 5(4):397-404. [PMID] 11945066.
77 citations | PubMed - 2002
Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene.
Gene therapy. 9(1):12-20. [PMID] 11850718.
235 citations | PubMed - 2001
Direct gene delivery strategies for the treatment of rheumatoid arthritis.
Drug discovery today. 6(5):259-267. [PMID] 11182599.
37 citations | PubMed - 2001
Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4.
Journal of immunology (Baltimore, Md. : 1950). 166(5):3499-505. [PMID] 11207309.
162 citations | PubMed - 2001
Future of adenoviruses in the gene therapy of arthritis.
Arthritis research. 3(3):142-6. [PMID] 11299054.
27 citations | PubMed - 2001
Gene therapy for rheumatoid arthritis.
Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand. 6(2):211-9. [PMID] 11901469.
8 citations | PubMed - 2001
Gene therapy for rheumatoid arthritis.
Expert opinion on biological therapy. 1(6):971-8. [PMID] 11728228.
12 citations | PubMed - 2001
Gene therapy for rheumatoid arthritis.
Current rheumatology reports. 3(1):79-85. [PMID] 11177774.
10 citations | PubMed - 2001
Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy. 3(6):901-10. [PMID] 11407904.
51 citations | PubMed - 2001
The effect of bone morphogenetic protein-2 expression on the early fate of skeletal muscle-derived cells.
Bone. 28(5):499-506. [PMID] 11344049.
36 citations | PubMed - 2000
Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining.
The journal of gene medicine. 2(3):210-9. [PMID] 10894267.
41 citations | PubMed - 2000
Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints.
Arthritis and rheumatism. 43(11):2563-70. [PMID] 11083281.
73 citations | PubMed - 2000
Cartilage injury and repair.
Physical medicine and rehabilitation clinics of North America. 11(2):289-307, vi. [PMID] 10810762.
32 citations | PubMed - 2000
Clinical trials in the gene therapy of arthritis.
Clinical orthopaedics and related research. (379 Suppl):S300-7. [PMID] 11039783.
52 citations | PubMed - 2000
Ex vivo gene therapy to produce bone using different cell types.
Clinical orthopaedics and related research. (378):290-305. [PMID] 10987005.
96 citations | PubMed - 2000
Gene therapy approaches for treating rheumatoid arthritis.
Clinical orthopaedics and related research. (379 Suppl):S288-99. [PMID] 11039782.
12 citations | PubMed - 2000
Gene therapy for autoimmune disorders.
Journal of clinical immunology. 20(5):334-46. [PMID] 11051275.
23 citations | PubMed - 2000
Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4.
Arthritis research. 2(4):293-302. [PMID] 11056670.
77 citations | PubMed - 2000
Gene therapy for rheumatoid arthritis.
Clinical orthopaedics and related research. (379 Suppl):S308-10. [PMID] 11039784.
PubMed - 2000
Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene.
Gene therapy. 7(9):734-9. [PMID] 10822299.
219 citations | PubMed - 2000
Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1.
Arthritis and rheumatism. 43(5):1156-64. [PMID] 10817570.
125 citations | PubMed - 2000
Potential applications of gene therapy in sports medicine.
Physical medicine and rehabilitation clinics of North America. 11(2):405-16. [PMID] 10810768.
2 citations | PubMed - 2000
Potential role of direct adenoviral gene transfer in enhancing fracture repair.
Clinical orthopaedics and related research. (379 Suppl):S120-5. [PMID] 11039760.
50 citations | PubMed - 2000
The efficiency of muscle-derived cell-mediated bone formation.
Cell transplantation. 9(4):463-70. [PMID] 11038063.
43 citations | PubMed - 2000
The Marshall R. Urist Young Investigator Award. Orthopaedic applications of gene therapy. From concept to clinic.
Clinical orthopaedics and related research. (375):324-37. [PMID] 10853185.
25 citations | PubMed - 2000
Using gene therapy to protect and restore cartilage.
Clinical orthopaedics and related research. (379 Suppl):S214-9. [PMID] 11039771.
63 citations | PubMed - 2000
Vector systems for gene transfer to joints.
Clinical orthopaedics and related research. (379 Suppl):S17-30. [PMID] 11039748.
55 citations | PubMed - 1999
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.
Diabetes. 48(9):1730-6. [PMID] 10480601.
132 citations | PubMed - 1999
Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone.
Bone. 24(6):541-7. [PMID] 10375195.
182 citations | PubMed - 1999
Clinical gene therapy for arthritis.
Drugs of today (Barcelona, Spain : 1998). 35(4-5):389-96. [PMID] 12973441.
4 citations | PubMed - 1999
Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees.
Journal of immunology (Baltimore, Md. : 1950). 163(4):2202-8. [PMID] 10438962.
119 citations | PubMed - 1999
Gene therapy for rheumatic diseases.
Arthritis and rheumatism. 42(1):1-16. [PMID] 9920008.
137 citations | PubMed - 1999
Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis.
Gene therapy. 6(10):1713-20. [PMID] 10516720.
85 citations | PubMed - 1999
Lessons learned from gene transfer approaches.
Arthritis research. 1(1):21-4. [PMID] 11094409.
16 citations | PubMed - 1999
The role of gene therapy. Fact or fiction?
Clinics in sports medicine. 18(1):223-39, vii. [PMID] 10028123.
6 citations | PubMed - 1998
Blocking cytokines with genes.
Journal of leukocyte biology. 64(1):55-61. [PMID] 9665275.
26 citations | PubMed - 1998
Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects.
Proceedings of the National Academy of Sciences of the United States of America. 95(8):4613-8. [PMID] 9539786.
244 citations | PubMed - 1998
Gene therapy in autoimmune diseases.
Annals of the rheumatic diseases. 57(3):125-7. [PMID] 9640124.
19 citations | PubMed - 1998
Viral vectors for gene therapy.
Trends in biotechnology. 16(1):35-40. [PMID] 9470229.
187 citations | PubMed - 1998
Viral vectors for gene therapy.
Pharmacology & therapeutics. 80(1):35-47. [PMID] 9804053.
310 citations | PubMed - 1997
Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950). 159(7):3604-12. [PMID] 9317160.
96 citations | PubMed - 1997
Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy.
Gene therapy. 4(9):977-82. [PMID] 9349435.
74 citations | PubMed - 1997
Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study.
Osteoarthritis and cartilage. 5(2):139-43. [PMID] 9135825.
105 citations | PubMed - 1997
Gene therapy for arthritis: principles and clinical practice.
Biochemical Society transactions. 25(2):533-7. [PMID] 9191150.
15 citations | PubMed - 1996
Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis.
Human gene therapy. 7(10):1261-80. [PMID] 8793551.
193 citations | PubMed - 1996
Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo.
Arthritis and rheumatism. 39(5):820-8. [PMID] 8639179.
146 citations | PubMed - 1996
Genomic footprinting of mitochondrial DNA: I. In organello analysis of protein-mitochondrial DNA interactions in bovine mitochondria.
Methods in enzymology. 264:12-22. [PMID] 8965685.
1 citation | PubMed - 1996
Genomic footprinting of mitochondrial DNA: II. In vivo analysis of protein-mitochondrial DNA interactions in Xenopus laevis eggs and embryos.
Methods in enzymology. 264:23-36. [PMID] 8965697.
2 citations | PubMed - 1994
In organello footprint analysis of human mitochondrial DNA: human mitochondrial transcription factor A interactions at the origin of replication.
Molecular and cellular biology. 14(12):7717-30. [PMID] 7969115.
84 citations | PubMed - 1993
In organello footprinting. Analysis of protein binding at regulatory regions in bovine mitochondrial DNA.
The Journal of biological chemistry. 268(12):8675-82. [PMID] 8473311.
29 citations | PubMed - 1993
In vivo and in vitro evidence for slipped mispairing in mammalian mitochondria.
Proceedings of the National Academy of Sciences of the United States of America. 90(16):7671-5. [PMID] 8356068.
85 citations | PubMed - 1993
Protein binding to a single termination-associated sequence in the mitochondrial DNA D-loop region.
Molecular and cellular biology. 13(4):2162-71. [PMID] 8455604.
74 citations | PubMed - 1993
Transcribed heteroplasmic repeated sequences in the porcine mitochondrial DNA D-loop region.
Journal of molecular evolution. 37(1):36-7. [PMID] 8360917.
79 citations | PubMed
Grants
- September 2022
Novel?coated?nanostructured implant surfaces to increase osseointegration and decrease peri-implantitis in a physiologic rat model
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR - August 2019
Development of a Novel AAV Vector Capsid Optimized for OA Gene Therapy
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION - June 2018 - August 2019
3D co-culture models to screen immune-oncology drug candidates
Role: Co-Project Director/Principal Investigator
Funding: MERCK SHARP & DOHME - May 2018 - November 2021
OR-DRPD-ROF2018: Developing a Novel In Vitro Model of Osteosarcoma by 3D printing in Liquid-Like Solids
Role: Co-Investigator
Funding: UF RESEARCH - May 2018
High throughput 3D printing
Role: Project Manager
Funding: MERCK SHARP & DOHME - June 2016 - September 2021
Novel coatings to minimize surface degradation and fracture susceptibility of dental ceramics
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR - July 2014 - September 2018
Gene Therapy for Post Traumatic Osteoarthritis
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION - June 2014 - June 2016
Development of AAV Vectors for Efficient Targeting and Elimination of Osteosarcoma Tumor-Initiating Cells
Role: Principal Investigator
Funding: ALEXS LEMONADE STAND FOUNDATION - August 2010 - May 2016
Delivery of Soluble FGFR3 as a Treatment for Achondroplasia
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS - June 2007 - August 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Patents
- Published October 2022
Growth Media for Three-Dimensional Cell Culture
US-2022-0333051-A1 - Issued July 2022
Growth Media for Three Dimensional Cell Culture
#11,390,835 - Issued December 2021
Methods and Compositions for Treating Conditions Using Recombinant Self-Complementary Adeno-Associated Virus
#11,207,382 - Issued December 2021
Fabrication of Autologous Bone
#1,119,794,611,197,946 - Published March 2020
Optimized Equine IL-1Ra cDNA
US-2020-0071371-A1 - Published September 2019
3D Micro Fabrication and Screening
US-2019-0270962-A1 - Published August 2008
The Use of Double-Stranded/ Self-Complementary Adeno-Associated Viral Vectors for Delivery of DNA to Treat Articular Diseases
US 2008/0187576 A1
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