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Padraic P Levings, PhD

Assistant Professor

Division: Research
Academic Office: (352) 273-7433
Business Email: levinpp@ortho.ufl.edu

About Padraic Levings

Gene Therapy Laboratory

Publications

  • 2022
    Gene Therapy in Orthopaedics: Progress and Challenges in Pre-Clinical Development and Translation.
    Frontiers in bioengineering and biotechnology. 10. [DOI] 10.3389/fbioe.2022.901317. [PMID] 35837555.
    2 citations  | PubMed  | Publisher's Site 
  • 2018
    Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.
    Human gene therapy. Clinical development. 29(2):90-100. [DOI] 10.1089/humc.2017.142. [PMID] 29869540.
    28 citations  | PubMed  | Publisher's Site 
  • 2018
    Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.
    Human gene therapy. Clinical development. 29(2):101-112. [DOI] 10.1089/humc.2017.143. [PMID] 29869535.
    19 citations  | PubMed  | Publisher's Site 
  • 2013
    scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.
    Gene therapy. 20(6):670-7. [DOI] 10.1038/gt.2012.81. [PMID] 23151520.
    45 citations  | PubMed  | Publisher's Site 
  • 2011
    Evidence for the osteosarcoma stem cell.
    Current orthopaedic practice. 22(4):322-326. [PMID] 21755019.
    31 citations  | PubMed 
  • 2010
    Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo.
    Laboratory investigation; a journal of technical methods and pathology. 90(11):1615-27. [DOI] 10.1038/labinvest.2010.145. [PMID] 20697373.
    49 citations  | PubMed  | Publisher's Site 
  • 2009
    Chondrogenesis of Bovine Mscs Is Influenced By Adenoviral-Mediated Delivery of Bmp-4, Bmp-7, Indian Hedgehog, and Sox-9
    Molecular Therapy. 17.
  • 2009
    Examining the Role of Elevated Blood Glucose in the Severity of Arthrofibrosis Using Intra-Articular Gene Delivery of Tgf-Beta 1
    Molecular Therapy. 17.
  • 2009
    Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma.
    Cancer research. 69(14):5648-55. [DOI] 10.1158/0008-5472.CAN-08-3580. [PMID] 19584295.
    137 citations  | PubMed  | Publisher's Site 
  • 2009
    Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.
    The journal of gene medicine. 11(7):605-14. [DOI] 10.1002/jgm.1334. [PMID] 19384892.
    44 citations  | PubMed  | Publisher's Site 
  • 2008
    Perspectives on the use of gene therapy for chronic joint diseases.
    Current gene therapy. 8(4):273-86. [PMID] 18691023.
    11 citations  | PubMed 
  • 2006
    Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta.
    Arthritis research & therapy. 8(6). [PMID] 17109745.
    51 citations  | PubMed 
  • 2006
    Recruitment of transcription complexes to the beta-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells.
    The FEBS journal. 273(4):746-55. [PMID] 16441661.
    29 citations  | PubMed 
  • 2004
    Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human beta-globin transgene in a centromeric region.
    Genes to cells : devoted to molecular & cellular mechanisms. 9(11):1043-53. [PMID] 15507116.
    6 citations  | PubMed 
  • 2004
    Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro.
    The Journal of biological chemistry. 279(48):50350-7. [PMID] 15385559.
    60 citations  | PubMed 
  • 2002
    The human beta-globin locus control region.
    European journal of biochemistry. 269(6):1589-99. [PMID] 11895428.
    110 citations  | PubMed 
  • 2001
    Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.
    Molecular and cellular biology. 21(8):2629-40. [PMID] 11283243.
    48 citations  | PubMed 

Patents

  • Published November 2020
    Perfusion Enabled Bioreactors
    US-2020-0354668-A1

Contact Details

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