In the News
Publications
- 2023
MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma
PLOS ONE. 18(1). [DOI] 10.1371/journal.pone.0278844. [PMID] 36701370.
PubMed | Publisher's Site - 2022
Gene Therapy in Orthopaedics: Progress and Challenges in Pre-Clinical Development and Translation.
Frontiers in bioengineering and biotechnology. 10. [DOI] 10.3389/fbioe.2022.901317. [PMID] 35837555.
2 citations | PubMed | Publisher's Site - 2020
Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.
Cells. 9(9). [DOI] 10.3390/cells9092072. [PMID] 32927859.
2 citations | PubMed | Publisher's Site - 2018
Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations.
European cells & materials. 36:156-170. [DOI] 10.22203/eCM.v036a12. [PMID] 30311630.
2 citations | PubMed | Publisher's Site - 2016
Liquid-like Solids Support Cells in 3D.
ACS biomaterials science & engineering. 2(10):1787-1795. [DOI] 10.1021/acsbiomaterials.6b00218. [PMID] 33440476.
50 citations | PubMed | Publisher's Site - 2015
Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(10):4107-21. [DOI] 10.1096/fj.15-272427. [PMID] 26092928.
40 citations | PubMed | Publisher's Site - 2014
F-Spondin Deficient Mice Have a High Bone Mass Phenotype
PLoS One. 9(5). [DOI] 10.1371/journal.pone.0098388. [PMID] 24875054.
17 citations | PubMed | Publisher's Site - 2010
F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 28(10):1323-9. [DOI] 10.1002/jor.21130. [PMID] 20839318.
14 citations | PubMed | Publisher's Site - 2009
Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer.
Tissue engineering. Part A. 15(5):1127-39. [DOI] 10.1089/ten.tea.2007.0252. [PMID] 18826340.
81 citations | PubMed | Publisher's Site - 2009
F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(1):79-89. [DOI] 10.1096/fj.08-114363. [PMID] 18780763.
37 citations | PubMed | Publisher's Site - 2009
Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways.
Arthritis and rheumatism. 60(3):801-12. [DOI] 10.1002/art.24352. [PMID] 19248089.
182 citations | PubMed | Publisher's Site - 2008
A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors.
Gene therapy. 15(5):357-63. [DOI] 10.1038/sj.gt.3303092. [PMID] 18283289.
13 citations | PubMed | Publisher's Site - 2008
In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament.
Biomaterials. 29(7):904-16. [PMID] 18045683.
23 citations | PubMed - 2007
Facilitated endogenous repair: making tissue engineering simple, practical, and economical.
Tissue engineering. 13(8):1987-93. [PMID] 17518747.
98 citations | PubMed - 2007
Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid.
Tissue engineering. 13(9):2227-37. [PMID] 17561802.
54 citations | PubMed - 2007
Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(6):1114-20. [PMID] 17440444.
40 citations | PubMed - 2005
Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(2):219-28. [PMID] 16043093.
107 citations | PubMed - 2004
Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes.
Osteoarthritis and cartilage. 12(3):217-24. [PMID] 14972338.
25 citations | PubMed - 2004
Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model.
Molecular therapy : the journal of the American Society of Gene Therapy. 10(2):327-36. [PMID] 15294179.
43 citations | PubMed - 2004
Gene delivery to cartilage defects using coagulated bone marrow aspirate.
Gene therapy. 11(2):133-41. [PMID] 14712297.
77 citations | PubMed - 2004
In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.
Methods in molecular medicine. 100:147-64. [PMID] 15280594.
17 citations | PubMed - 2003
A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer.
Arthritis research & therapy. 5(5):R301-9. [PMID] 12932294.
32 citations | PubMed - 2003
Disparate aggrecan gene expression in chondrocytes subjected to hypotonic and hypertonic loading in 2D and 3D culture.
Biorheology. 40(1-3):61-72. [PMID] 12454388.
25 citations | PubMed - 2003
Gene transfer to articular chondrocytes with recombinant adenovirus.
Methods in molecular biology (Clifton, N.J.). 215:235-46. [PMID] 12512303.
27 citations | PubMed - 2003
Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy. 7(4):460-6. [PMID] 12727108.
64 citations | PubMed - 2002
In vivo gene delivery to synovium by lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy. 5(4):397-404. [PMID] 11945066.
77 citations | PubMed - 2001
Gene therapy for rheumatoid arthritis.
Expert opinion on biological therapy. 1(6):971-8. [PMID] 11728228.
12 citations | PubMed - 2001
Gene therapy for rheumatoid arthritis.
Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand. 6(2):211-9. [PMID] 11901469.
8 citations | PubMed - 2001
Time-dependent aggrecan gene expression of articular chondrocytes in response to hyperosmotic loading.
Osteoarthritis and cartilage. 9(8):761-70. [PMID] 11795996.
32 citations | PubMed - 1998
Regulatory activities of the 5'- and 3'-untranslated regions and promoter of the human aggrecan gene.
The Journal of biological chemistry. 273(11):6196-202. [PMID] 9497342.
22 citations | PubMed - 1995
Structure of the human aggrecan gene: exon-intron organization and association with the protein domains.
The Biochemical journal. 309 ( Pt 2)(Pt 2):535-42. [PMID] 7626017.
54 citations | PubMed
Grants
- January 2022
Advanced Liver 3-D Tissue Models for Drug Development Applications to Support Toxicology, Drug Metabolism, Target ID, & Pharmacology
Role: Co-Project Director/Principal Investigator
Funding: ADV REGENERATIVE MANUFACTURING INST via US ARMY RESEARCH LABORATORY - March 2020
Cell Cycle-Mediated Optimization of Cartilage Tissue Development
Role: Principal Investigator
Funding: COLUMBIA UNIVERSITY via NATL INST OF HLTH NIAMS - August 2019
Development of a Novel AAV Vector Capsid Optimized for OA Gene Therapy
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION - May 2018 - November 2021
OR-DRPD-ROF2018: Developing a Novel In Vitro Model of Osteosarcoma by 3D printing in Liquid-Like Solids
Role: Principal Investigator
Funding: UF RESEARCH - March 2017 - March 2021
Advanced Liver 3-D Tissue Models for Drug Development Applications to Support Toxicology, Drug Metabolism, Target ID & Pharmacology
Role: Faculty
Funding: ADV REGENERATIVE MANUFACTURING INST via US ARMY RESEARCH LABORATORY - March 2016 - March 2019
Transcriptional reporters for quantitative assessment of chondrocyte differentiation in-vitro and in-vivo
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS - January 2016 - June 2016
Soft Matter Manufacturing: Life Science, Medicine, and Medical Fabrication
Role: Project Manager
Funding: LUBRIZOL CORPORATION - June 2007 - August 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Patents
- Published October 2022
Growth Media for Three-Dimensional Cell Culture
US-2022-0333051-A1 - Issued July 2022
Growth Media for Three Dimensional Cell Culture
#11,390,835
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